Short-Term Outcomes and Medical and Surgical Interventions in Infants with Congenital Diaphragmatic Hernia

Theresa R. Grover, Karna Murthy, Beverly Brozanski, Jason Gien, Natalie Rintoul, Sarah Keene, Tasnim Najaf, Louis Chicoine, Nicolas Porta, Isabella Zaniletti, Eugenia K. Pallotto

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32 Scopus citations


Objective The aim of this study is to characterize medical and surgical therapies and short-term outcomes in infants with congenital diaphragmatic hernia (CDH). Study Design Retrospective analysis of CDH infants admitted to 27 children's hospitals submitting data to Children's Hospital Neonatal Database (CHND) from 2010 to 2013, stratified by gestational age, birth weight, and survival. Results A total of 572 infants were identified, 508 (89%) born ≥ 34 weeks' gestation and ≥ 2 kg. More mature infants had higher APGAR scores, shorter duration of mechanical ventilation, and were more likely to receive extracorporeal membrane oxygenation (ECMO). Overall, mortality for the cohort was 29%, with mortality lower in infants born ≥ 34 weeks' gestation and ≥ 2 kg (26 vs. 50%, p < 0.01). Nonsurvivors were more likely to receive treatment with high-frequency oscillatory ventilation (HFOV), vasopressors, pulmonary vasodilators, and ECMO, and to have associated major congenital anomalies than survivors. In hospital morbidity and complications were relatively uncommon among survivors. Conclusion Infants with CDH have a high risk of morbidity and mortality, and for preterm infants with CDH those risks are amplified. Patterns of respiratory and circulatory support appeared to be different for survivors. In addition to established data registries, this consortium of regional neonatal intensive care units provides a new collaborative effort to describe short-term outcomes for infants referred with CDH.

Original languageEnglish
Pages (from-to)1038-1044
Number of pages7
JournalAmerican journal of perinatology
Issue number11
StatePublished - Mar 31 2015


  • NICU
  • congenital diaphragmatic hernia
  • neonatal
  • prematurity
  • pulmonary hypertension
  • pulmonary hypoplasia
  • respiratory failure


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