Purpose: To report the trends in intraocular pressures (IOP) within the first week after intravitreal injection of triamcinolone acetonide (Kenalog) for the treatment of retinal disease. Design: Retrospective chart review. Methods: Review of 43 consecutive patients and 50 intravitreal injections of 4 mg triamcinolone acetonide. Analysis of the effect on IOP was performed. Results: The mean preinjection IOP was 14.60 ± 3.71 mm Hg (mean ± SD) (range, 9 to 26 mm Hg). The mean postinjection IOP (30 minutes after injection) was 19.64 ± 7.43 mm Hg (range, 5 to 45 mm Hg). Mean IOP change before and after injection was 4.83 ± 7.10 mm Hg. The mean IOP one to two days after injection was 15.32 ± 4.41. mm Hg (range, 6 to 27 mm Hg). The mean IOP five to seven days after injection was 15.94 ± 4.86 mm Hg (range, 5 to 28 mm Hg). Conclusions: Intravitreal triamcinolone acetonide injection in this limited series does not cause a marked increase in IOP within the first week after the procedure.