TY - JOUR
T1 - Short-term deceleration capacity of heart rate
T2 - a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson’s disease
AU - Carricarte Naranjo, Claudia
AU - Marras, Connie
AU - Visanji, Naomi P.
AU - Cornforth, David J.
AU - Sanchez‑Rodriguez, Lazaro
AU - Schüle, Birgitt
AU - Goldman, Samuel M.
AU - Estévez, Mario
AU - Stein, Phyllis K.
AU - Lang, Anthony E.
AU - Jelinek, Herbert F.
AU - Machado, Andrés
N1 - Funding Information:
This paper is dedicated to the memory of Professor Mario Estévez Báez, an outstanding scientist who devoted his life to human physiology research, through his extensive studies on the assessment of autonomic nervous system and methodological aspects of HRV analysis. The authors would like to thank all participants for their valuable contribution to this study. This work was facilitated by a travel grant awarded by the International Parkinson and Movement Disorder Society Pan American Section to CCN. The study was funded by a research grant awarded by The Michael J. Fox Foundation for Parkinson’s Research to CM and BS.
Funding Information:
This paper is dedicated to the memory of Professor Mario Estévez Báez, an outstanding scientist who devoted his life to human physiology research, through his extensive studies on the assessment of autonomic nervous system and methodological aspects of HRV analysis. The authors would like to thank all participants for their valuable contribution to this study. This work was facilitated by a travel grant awarded by the International Parkinson and Movement Disorder Society Pan American Section to CCN. The study was funded by a research grant awarded by The Michael J. Fox Foundation for Parkinson’s Research to CM and BS.
Funding Information:
This work was supported by the Michael J. Fox Foundation for Parkinson’s Research [Grant Number MJFF 6896].
Publisher Copyright:
© 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/12
Y1 - 2021/12
N2 - Purpose: Cardiac autonomic dysfunction in idiopathic Parkinson’s disease (PD) manifests as reduced heart rate variability (HRV). In the present study, we explored the deceleration capacity of heart rate (DC) in patients with idiopathic PD, an advanced HRV marker that has proven clinical utility. Methods: Standard and advanced HRV measures derived from 7-min electrocardiograms in 20 idiopathic PD patients and 27 healthy controls were analyzed. HRV measures were compared using regression analysis, controlling for age, sex, and mean heart rate. Results: Significantly reduced HRV was found only in the subcohort of PD patients older than 60 years. Low- frequency power and global HRV measures were lower in patients than in controls, but standard beat-to-beat HRV markers (i.e., rMSSD and high-frequency power) were not significantly different between groups. DC was significantly reduced in the subcohort of PD patients older than 60 years compared to controls. Conclusions: Deceleration-related oscillations of HRV were significantly reduced in the older PD patients compared to healthy controls, suggesting that short-term DC may be a sensitive marker of cardiac autonomic dysfunction in PD. DC may be complementary to traditional markers of short-term HRV for the evaluation of autonomic modulation in PD. Further study to examine the association between DC and cardiac adverse events in PD is needed to clarify the clinical relevance of DC in this population.
AB - Purpose: Cardiac autonomic dysfunction in idiopathic Parkinson’s disease (PD) manifests as reduced heart rate variability (HRV). In the present study, we explored the deceleration capacity of heart rate (DC) in patients with idiopathic PD, an advanced HRV marker that has proven clinical utility. Methods: Standard and advanced HRV measures derived from 7-min electrocardiograms in 20 idiopathic PD patients and 27 healthy controls were analyzed. HRV measures were compared using regression analysis, controlling for age, sex, and mean heart rate. Results: Significantly reduced HRV was found only in the subcohort of PD patients older than 60 years. Low- frequency power and global HRV measures were lower in patients than in controls, but standard beat-to-beat HRV markers (i.e., rMSSD and high-frequency power) were not significantly different between groups. DC was significantly reduced in the subcohort of PD patients older than 60 years compared to controls. Conclusions: Deceleration-related oscillations of HRV were significantly reduced in the older PD patients compared to healthy controls, suggesting that short-term DC may be a sensitive marker of cardiac autonomic dysfunction in PD. DC may be complementary to traditional markers of short-term HRV for the evaluation of autonomic modulation in PD. Further study to examine the association between DC and cardiac adverse events in PD is needed to clarify the clinical relevance of DC in this population.
KW - Cardiac autonomic modulation
KW - Deceleration capacity of heart rate
KW - Heart rate variability
KW - Idiopathic Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85110609765&partnerID=8YFLogxK
U2 - 10.1007/s10286-021-00815-4
DO - 10.1007/s10286-021-00815-4
M3 - Article
C2 - 34251546
AN - SCOPUS:85110609765
SN - 0959-9851
VL - 31
SP - 729
EP - 736
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 6
ER -