Short-term and long-term effects of noninvasive cardiac radioablation for ventricular tachycardia: A single-center case series

Won Ick Chang, Ha Hye Jo, Myung Jin Cha, Ji Hyun Chang, Chang Heon Choi, Hak Jae Kim, Seil Oh, Clifford G. Robinson, Phillip S. Cuculich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Noninvasive cardiac radioablation is reported to be effective and safe for the treatment of ventricular tachycardia (VT). Objective: This study aimed to analyze the acute and long-term effects of VT radioablation. Methods: Patients with intractable VT or premature ventricular contraction (PVC)–induced cardiomyopathy were included in this study and treated using a single-fraction 25-Gy dose of cardiac radioablation. To quantitatively analyze the acute response after treatment, continuous electrocardiography monitoring was performed from 24 hours before to 48 hours after irradiation and at the 1-month follow-up. Long-term clinical safety and efficacy were assessed 1-year follow-up. Results: From 2019 to 2020, 6 patients were treated with radioablation for ischemic VT (n = 3), nonischemic VT (n = 2), or PVC-induced cardiomyopathy (n = 1). In the short-term assessment, the total burden of ventricular beats decreased by 49% within 24 hours after radioablation and further decreased by 70% at 1 month. The VT component decreased earlier and more dramatically than the PVC component (decreased by 91% and 57% at 1 month, respectively). In the long-term assessment, 5 patients showed complete (n = 3) or partial (n = 2) remission of ventricular arrhythmias. One patient showed recurrence at 10 months, which was successfully suppressed with medical treatment. The posttreatment PVC coupling interval was prolonged (+38 ms at 1 month). Ischemic VT burden decreased more markedly than nonischemic VT burden after radioablation. Conclusion: In this small case series of 6 patients, without a comparison group, cardiac radioablation appeared to decrease the intractable VT burden. A therapeutic effect was apparent within 1–2 days after treatment but was variable by etiology of cardiomyopathy.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalHeart Rhythm O2
Issue number2
StatePublished - Feb 2023


  • Cardiac radioablation
  • Early antiarrhythmic effect
  • Electrophysiologic change
  • Safety
  • Ventricular tachycardia


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