TY - JOUR
T1 - Short report
T2 - Semi-quantitative scoring of an immunochromatographic test for circulating filarial antigen
AU - Chesnais, Cédric B.
AU - Missamou, François
AU - Pion, Sébastien D.S.
AU - Bopda, Jean
AU - Louya, Frédéric
AU - Majewski, Andrew C.
AU - Weil, Gary J.
AU - Boussinesq, Michel
PY - 2013/11
Y1 - 2013/11
N2 - The value of a semi-quantitative scoring of the filarial antigen test (Binax Now Filariasis card test, ICT) results was evaluated during a field survey in the Republic of Congo. One hundred and thirty-four (134) of 774 tests (17.3%) were clearly positive and were scored 1, 2, or 3; and 11 (1.4%) had questionable results. Wuchereria bancrofti microfilariae (mf) were detected in 41 of those 133 individuals with an ICT test score ≥ 1 who also had a night blood smear; none of the 11 individuals with questionable ICT results harbored night mf. Cuzick's test showed a significant trend for higher microfilarial densities in groups with higher ICT scores (P < 0.001). The ICT scores were also significantly correlated with blood mf counts. Because filarial antigen levels provide an indication of adult worm infection intensity, our results suggest that semi-quantitative reading of the ICT may be useful for grading the intensity of filarial infections in individuals and populations.
AB - The value of a semi-quantitative scoring of the filarial antigen test (Binax Now Filariasis card test, ICT) results was evaluated during a field survey in the Republic of Congo. One hundred and thirty-four (134) of 774 tests (17.3%) were clearly positive and were scored 1, 2, or 3; and 11 (1.4%) had questionable results. Wuchereria bancrofti microfilariae (mf) were detected in 41 of those 133 individuals with an ICT test score ≥ 1 who also had a night blood smear; none of the 11 individuals with questionable ICT results harbored night mf. Cuzick's test showed a significant trend for higher microfilarial densities in groups with higher ICT scores (P < 0.001). The ICT scores were also significantly correlated with blood mf counts. Because filarial antigen levels provide an indication of adult worm infection intensity, our results suggest that semi-quantitative reading of the ICT may be useful for grading the intensity of filarial infections in individuals and populations.
UR - http://www.scopus.com/inward/record.url?scp=84888619226&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.13-0245
DO - 10.4269/ajtmh.13-0245
M3 - Article
C2 - 24019435
AN - SCOPUS:84888619226
SN - 0002-9637
VL - 89
SP - 916
EP - 918
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -