TY - JOUR
T1 - Shared transcriptional control of innate lymphoid cell and dendritic cell development
AU - Bagadia, Prachi
AU - Huang, Xiao
AU - Liu, Tian Tian
AU - Murphy, Kenneth M.
N1 - Publisher Copyright:
© 2019 Annual Reviews Inc.. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.
AB - Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.
KW - T cells
KW - dendritic cells
KW - hematopoiesis
KW - innate lymphoid cells
KW - transcription factors
UR - http://www.scopus.com/inward/record.url?scp=85072159092&partnerID=8YFLogxK
U2 - 10.1146/annurev-cellbio-100818-125403
DO - 10.1146/annurev-cellbio-100818-125403
M3 - Review article
C2 - 31283378
AN - SCOPUS:85072159092
SN - 1081-0706
VL - 35
SP - 381
EP - 406
JO - Annual Review of Cell and Developmental Biology
JF - Annual Review of Cell and Developmental Biology
ER -