Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.

Original languageEnglish
Pages (from-to)381-406
Number of pages26
JournalAnnual Review of Cell and Developmental Biology
StatePublished - 2019


  • T cells
  • dendritic cells
  • hematopoiesis
  • innate lymphoid cells
  • transcription factors


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