Shared T Cell Epitopes in Epithelial Tumors

George E. Peoples, Roy C. Smith, David C. Linehan, Ichiro Yoshino, Peter S. Goedegebuure, Timothy J. Eberlein

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


We have previously shown the importance of human leukocyte antigen (HLA)-A2 and the proto-oncogene HER2/neu in the T cell recognition of ovarian cancer. Since these proteins are ubiquitously expressed in epithelial-derived tumors, we have acid-eluted HLA-bound peptides from ovarian cancers, fractionated the peptides, and reconstituted T cell epitopes on the HLA-A2+ T2 cell line to determine if common tumor-associated antigens exist among HLA-A2+, HER2/neu+ epithelial cancers. We demonstrate that tumor-specific cytotoxic T lymphocytes (CTL) generated from tumor-infiltrating lymphocytes isolated from three ovarian, two breast, and two non-small-cell lung cancers recognize at least three of the same peptide fractions from multiple elutions. One of these peptide fractions co-elutes with a HER2/neu-derived peptide which has been shown recently to be recognized by these same CTL. These findings demonstrate that a common peptide-based tumor vaccine is theoretically possible for many different epithelial-derived cancers.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalCellular Immunology
Issue number2
StatePublished - Sep 1995


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