TY - JOUR
T1 - Sexual dimorphism of the human corpus callosum studied by magnetic resonance imaging
T2 - Fact, fallacy and statistical confidence
AU - Elster, Allen D.
AU - DiPersio, Deborah A.
AU - Moody, Dixon M.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Magnetic resonance (MR) imaging was performed in 120 normal right-handed individuals (60 males, 60 females) to clarify existing contradictory data concerning possible sexual dimorphism of the human corpus callosum (CC). Five linear and three area measurements of the CC and brain were obtained directly at the MR scanner console from midline sagittal T1-weighted images. The anteroposterior length of the CC was significantly larger in males than in females (p = 0.0005). No other differences in absolute callosal measurements between the sexes could be demonstrated. However, several size ratios did achieve statistical significance (p < 0.05), being consistently larger in females: splenial width/length CC, splenial width/brain length, and area of CC/area of brain. Where no statistically significant differences were obtained, precision, tolerance, and confidence interval calculations are presented. The data in this large series support a limited but definite sexual dimorphism of the CC in right-handed individuals.
AB - Magnetic resonance (MR) imaging was performed in 120 normal right-handed individuals (60 males, 60 females) to clarify existing contradictory data concerning possible sexual dimorphism of the human corpus callosum (CC). Five linear and three area measurements of the CC and brain were obtained directly at the MR scanner console from midline sagittal T1-weighted images. The anteroposterior length of the CC was significantly larger in males than in females (p = 0.0005). No other differences in absolute callosal measurements between the sexes could be demonstrated. However, several size ratios did achieve statistical significance (p < 0.05), being consistently larger in females: splenial width/length CC, splenial width/brain length, and area of CC/area of brain. Where no statistically significant differences were obtained, precision, tolerance, and confidence interval calculations are presented. The data in this large series support a limited but definite sexual dimorphism of the CC in right-handed individuals.
KW - Corpus callosum
KW - brain-anatomy
KW - brain-development
KW - magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=0025282473&partnerID=8YFLogxK
U2 - 10.1016/S0387-7604(12)80314-7
DO - 10.1016/S0387-7604(12)80314-7
M3 - Article
C2 - 2403203
AN - SCOPUS:0025282473
SN - 0387-7604
VL - 12
SP - 321
EP - 325
JO - Brain and Development
JF - Brain and Development
IS - 3
ER -