TY - JOUR
T1 - Sexual Differentiation Specifies Cellular Responses to DNA Damage
AU - Broestl, Lauren
AU - Rubin, Joshua B.
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.
AB - Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.
KW - DNA repair
KW - radiation
KW - senescence
KW - sex differences
KW - sexual differentiation
UR - http://www.scopus.com/inward/record.url?scp=85117017122&partnerID=8YFLogxK
U2 - 10.1210/endocr/bqab192
DO - 10.1210/endocr/bqab192
M3 - Review article
C2 - 34478502
AN - SCOPUS:85117017122
SN - 0013-7227
VL - 162
JO - Endocrinology (United States)
JF - Endocrinology (United States)
IS - 11
M1 - bqab192
ER -