Sexual Differentiation Specifies Cellular Responses to DNA Damage

Lauren Broestl, Joshua B. Rubin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.

Original languageEnglish
Article numberbqab192
JournalEndocrinology (United States)
Volume162
Issue number11
DOIs
StatePublished - Nov 1 2021

Keywords

  • DNA repair
  • radiation
  • senescence
  • sex differences
  • sexual differentiation

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