TY - JOUR
T1 - Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
AU - Whitmire, Paula
AU - Rickertsen, Cassandra R.
AU - Hawkins-Daarud, Andrea
AU - Carrasco, Eduardo
AU - Lorence, Julia
AU - De Leon, Gustavo
AU - Curtin, Lee
AU - Bayless, Spencer
AU - Clark-Swanson, Kamala
AU - Peeri, Noah C.
AU - Corpuz, Christina
AU - Lewis-De Los Angeles, Christine Paula
AU - Bendok, Bernard R.
AU - Gonzalez-Cuyar, Luis
AU - Vora, Sujay
AU - Mrugala, Maciej M.
AU - Hu, Leland S.
AU - Wang, Lei
AU - Porter, Alyx
AU - Kumthekar, Priya
AU - Johnston, Sandra K.
AU - Egan, Kathleen M.
AU - Gatenby, Robert
AU - Canoll, Peter
AU - Rubin, Joshua B.
AU - Swanson, Kristin R.
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/5/19
Y1 - 2020/5/19
N2 - Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
AB - Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
KW - Biomathematical models
KW - Glioblastoma
KW - Neuroimaging
KW - Sex differences
UR - http://www.scopus.com/inward/record.url?scp=85084964990&partnerID=8YFLogxK
U2 - 10.1186/s12885-020-06816-2
DO - 10.1186/s12885-020-06816-2
M3 - Article
C2 - 32429869
AN - SCOPUS:85084964990
SN - 1471-2407
VL - 20
JO - BMC Cancer
JF - BMC Cancer
IS - 1
M1 - 447
ER -