TY - JOUR
T1 - Sex-Specific Differences in Patients with IDH1–Wild-Type Grade 4 Glioma in the ReSPOND Consortium
AU - on behalf of the ReSPOND Consortium
AU - Gongala, Sree
AU - Garcia, Jose A.
AU - Korakavi, Nisha
AU - Patil, Nirav
AU - Akbari, Hamed
AU - Sloan, Andrew
AU - Barnholtz-Sloan, Jill S.
AU - Sun, Jessie
AU - Griffith, Brent
AU - Poisson, Laila M.
AU - Booth, Thomas C.
AU - Jain, Rajan
AU - Mohan, Suyash
AU - Nasralla, MacLean P.
AU - Bakas, Spyridon
AU - Tippareddy, Charit
AU - Puig, Josep
AU - Palmer, Joshua D.
AU - Shi, Wenyin
AU - Colen, Rivka R.
AU - Sotiras, Aristeidis
AU - Soo Ahn, Sung
AU - Park, Yae Won
AU - Davatzikos, Christos
AU - Badve, Chaitra
N1 - Publisher Copyright:
© 2024 American Society of Neuroradiology. All rights reserved.
PY - 2024/9
Y1 - 2024/9
N2 - BACKGROUND AND PURPOSE: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type (IDH1-WT), grade 4. MATERIALS AND METHODS: Retrospective data of 1832 patients with glioblastoma, IDH1-WT with comprehensive information on tumor parameters was acquired from the Radiomics Signatures for Precision Oncology in Glioblastoma consortium. Data imputation was performed for missing values. Sex-based differences in tumor parameters, such as age, molecular parameters, preoperative Karnofsky performance score (KPS), tumor volumes, epicenter, and laterality were assessed through nonparametric tests. Spatial atlases were generated by using preoperative MRI maps to visualize tumor characteristics. Survival time analysis was performed through log-rank tests and Cox proportional hazard analyses. RESULTS: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] ¼ 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR ¼ 0.044). Women had lower tumor volumes in enhancing (16.7 cm3 versus 20.6 cm3 in men, FDR ¼ 0.001), necrotic core (6.18 cm3 versus 7.76 cm3 in men, FDR ¼ 0.001), and edema regions (46.9 cm3 versus 59.2 cm3 in men, FDR ¼ 0.0001). The right temporal region was the most common tumor epicenter in the overall population. Right as well as left temporal lobes were more frequently involved in men. There were no sex-specific differences in survival outcomes and mortality ratios. Higher age, unmethylated O6-methylguanine-DNA-methyltransferase promoter and undergoing subtotal resection increased the mortality risk in both men and women. CONCLUSIONS: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.
AB - BACKGROUND AND PURPOSE: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type (IDH1-WT), grade 4. MATERIALS AND METHODS: Retrospective data of 1832 patients with glioblastoma, IDH1-WT with comprehensive information on tumor parameters was acquired from the Radiomics Signatures for Precision Oncology in Glioblastoma consortium. Data imputation was performed for missing values. Sex-based differences in tumor parameters, such as age, molecular parameters, preoperative Karnofsky performance score (KPS), tumor volumes, epicenter, and laterality were assessed through nonparametric tests. Spatial atlases were generated by using preoperative MRI maps to visualize tumor characteristics. Survival time analysis was performed through log-rank tests and Cox proportional hazard analyses. RESULTS: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] ¼ 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR ¼ 0.044). Women had lower tumor volumes in enhancing (16.7 cm3 versus 20.6 cm3 in men, FDR ¼ 0.001), necrotic core (6.18 cm3 versus 7.76 cm3 in men, FDR ¼ 0.001), and edema regions (46.9 cm3 versus 59.2 cm3 in men, FDR ¼ 0.0001). The right temporal region was the most common tumor epicenter in the overall population. Right as well as left temporal lobes were more frequently involved in men. There were no sex-specific differences in survival outcomes and mortality ratios. Higher age, unmethylated O6-methylguanine-DNA-methyltransferase promoter and undergoing subtotal resection increased the mortality risk in both men and women. CONCLUSIONS: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.
UR - http://www.scopus.com/inward/record.url?scp=85203855826&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A8319
DO - 10.3174/ajnr.A8319
M3 - Article
C2 - 38684319
AN - SCOPUS:85203855826
SN - 0195-6108
VL - 45
SP - 1299
EP - 1307
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 9
ER -