Evidence for a sex-linked determinant of immunoglobulin M levels was sought using correlational and commingling analyses in a sample of 174 randomly selected nuclear families. While mean IgM levels in females were approximately 25% higher than that in males, the pattern of familial correlations did not follow the expectations under a sex-linked model, and there was no commingling in the distribution of IgM levels as expected when a trait is under the influence of a major gene.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalHuman heredity
Issue number4
StatePublished - 1990


  • immunoglobulin M
  • inheritance
  • sex-linked


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