Sex differences in the cerebral blood flow response after brief hypercapnia in the rat

Beau M. Ances, Joel H. Greenberg, John A. Detre

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Hypercapnia primarily affects cerebral blood flow (CBF) and not cerebral metabolism. We compared the CBF responses due to electrical forepaw stimulation before and after brief hypercapnia in male, non-ovarectomized female, and ovarectomized female rats. Prior to hypercapnia the CBF responses were similar for all three groups. Seven minutes after brief hypercapnic exposure the CBF responses to forepaw stimulation were augmented in all groups. However, both 30 and 60 min after hypercapnia, the magnitude of the CBF responses to forepaw stimulation remained elevated for males and ovarectomized females, but not for non-ovarectomized females. These results suggest that estrogen may modulate the upregulation of the CBF response observed after transient hypercapnia.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume304
Issue number1-2
DOIs
StatePublished - May 18 2001

Keywords

  • Cerebral blood flow
  • Laser-Doppler flowmetry
  • Somatosensory cortex

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