Abstract
Many studies report sex differences in multiple facets of human brain aging. This article aims to provide a survey of these studies across various topics, including cognitive aging, changes in brain structure, metabolism and function, and neurodegenerative and cerebrovascular diseases. We also discuss sex differences in aging in general as well as statistical issues pertinent to this topic. We conclude that sex differences in brain aging likely arise from multiple complex mechanisms that might impact clinical outcomes and treatment decisions, and thus require further and deeper investigations.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of the Human Brain, Second Edition |
| Subtitle of host publication | Volumes 1-5 |
| Publisher | Elsevier |
| Pages | V3-686-V3-697 |
| ISBN (Electronic) | 9780128204818 |
| ISBN (Print) | 9780128204801 |
| DOIs | |
| State | Published - Jan 1 2024 |
Keywords
- Alzheimer disease
- Ascertainment bias
- Brain aging
- Brain imaging
- Brain resilience
- Cerebral small vessel disease
- Cerebrovascular disease
- Cognitive aging
- Longevity
- Sex differences
- Survival bias