Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.

Original languageEnglish
Pages (from-to)870-872
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Issue number11
StatePublished - Nov 2009


  • Ceftriaxone
  • Cerebral ischemia
  • Hemolysis
  • Sickle cell disease


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