TY - JOUR
T1 - Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease
AU - Schuettpelz, Laura G.
AU - Behrens, Deanna
AU - Goldsmith, Matthew I.
AU - Druley, Todd E.
PY - 2009/11
Y1 - 2009/11
N2 - Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.
AB - Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.
KW - Ceftriaxone
KW - Cerebral ischemia
KW - Hemolysis
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=74249099890&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e3181b7eda2
DO - 10.1097/MPH.0b013e3181b7eda2
M3 - Article
C2 - 19829151
AN - SCOPUS:74249099890
SN - 1077-4114
VL - 31
SP - 870
EP - 872
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 11
ER -