TY - JOUR
T1 - Severe Asthma in School-Age Children
T2 - Evaluation and Phenotypic Advances
AU - Coverstone, Andrea
AU - Bacharier, Leonard B.
AU - Fitzpatrick, Anne M.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/5/3
Y1 - 2015/5/3
N2 - Although the majority of children with asthma have a favorable clinical response to treatment with low to moderate doses of inhaled corticosteroids (ICS), a small subset of children have “severe” asthma characterized by ongoing symptoms and airway inflammation despite treatment with high doses of ICS and even oral corticosteroids. Although there is symptom heterogeneity in the affected children, children with severe asthma share the risk for adverse outcomes, including recurrent and potentially life-threatening exacerbations, which contribute to substantial economic burden. This article reviews current knowledge of severe asthma in school-age children (age 6–17 years) with a focus on recent literature published after January 2012. Clinical management approaches for children with severe asthma are discussed as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe asthma in the future.
AB - Although the majority of children with asthma have a favorable clinical response to treatment with low to moderate doses of inhaled corticosteroids (ICS), a small subset of children have “severe” asthma characterized by ongoing symptoms and airway inflammation despite treatment with high doses of ICS and even oral corticosteroids. Although there is symptom heterogeneity in the affected children, children with severe asthma share the risk for adverse outcomes, including recurrent and potentially life-threatening exacerbations, which contribute to substantial economic burden. This article reviews current knowledge of severe asthma in school-age children (age 6–17 years) with a focus on recent literature published after January 2012. Clinical management approaches for children with severe asthma are discussed as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe asthma in the future.
KW - Asthma diagnosis
KW - Asthma evaluation
KW - Asthma phenotype
KW - Asthma treatment
KW - Children
KW - Severe asthma
UR - http://www.scopus.com/inward/record.url?scp=84934274408&partnerID=8YFLogxK
U2 - 10.1007/s11882-015-0521-5
DO - 10.1007/s11882-015-0521-5
M3 - Review article
C2 - 26134431
AN - SCOPUS:84934274408
SN - 1529-7322
VL - 15
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 5
M1 - 20
ER -