Severe Asthma in Children

Theresa W. Guilbert, Leonard B. Bacharier, Anne M. Fitzpatrick

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or comorbidities, or poor adherence due to adverse psychological or environmental factors. In contrast, treatment resistant is defined as difficult asthma despite management of these factors. It is increasingly recognized that severe asthma is a highly heterogeneous disorder associated with a number of clinical and inflammatory phenotypes that have been described in children with severe asthma. Guideline-based drug therapy of severe childhood asthma is based primarily on extrapolated data from adult studies. The recommendation is that children with severe asthma be treated with higher-dose inhaled or oral corticosteroids combined with long-acting β-agonists and other add-on therapies, such as antileukotrienes and methylxanthines. It is important to identify and address the influences that make asthma difficult to control, including reviewing the diagnosis and removing causal or aggravating factors. Better definition of the phenotypes and better targeting of therapy based upon individual patient phenotypes is likely to improve asthma treatment in the future.

Original languageEnglish
Pages (from-to)489-500
Number of pages12
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number5
StatePublished - 2014


  • Childhood difficult-to-treat asthma
  • Childhood severe asthma
  • Childhood severe asthma treatment
  • Review
  • Severe asthma phenotypes


Dive into the research topics of 'Severe Asthma in Children'. Together they form a unique fingerprint.

Cite this