TY - JOUR
T1 - Set it and forget it
T2 - Engineered cells for drug delivery
AU - Herzog, Erik D.
AU - Pham, Christine T.N.
AU - Guilak, Farshid
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2025/12/17
Y1 - 2025/12/17
N2 - Society needs alternatives to painful, expensive, and cumbersome injections for diseases like diabetes. Franko et al. developed cells that sense melatonin to deliver glucagon-like peptide-1 (GLP-1) therapy during sleep. This circadian-synchronized approach restored normal blood sugar in diabetic mice, advancing the field of smart cells for patient-centered circadian medicine.
AB - Society needs alternatives to painful, expensive, and cumbersome injections for diseases like diabetes. Franko et al. developed cells that sense melatonin to deliver glucagon-like peptide-1 (GLP-1) therapy during sleep. This circadian-synchronized approach restored normal blood sugar in diabetic mice, advancing the field of smart cells for patient-centered circadian medicine.
UR - https://www.scopus.com/pages/publications/105024599483
U2 - 10.1016/j.cels.2025.101484
DO - 10.1016/j.cels.2025.101484
M3 - Comment/debate
C2 - 41412109
AN - SCOPUS:105024599483
SN - 2405-4712
VL - 16
JO - Cell Systems
JF - Cell Systems
IS - 12
M1 - 101484
ER -