TY - JOUR
T1 - Serum testosterone changes in patients treated with radiation therapy alone for prostate cancer on NRG oncology RTOG 9408
AU - Nichols, R. Charles
AU - Hu, Chen
AU - Bahary, Jean Paul
AU - Zeitzer, Kenneth L.
AU - Souhami, Luis
AU - Leibenhaut, Mark H.
AU - Rotman, Marvin
AU - Gore, Elizabeth M.
AU - Balogh, Alexander G.
AU - McGowan, David
AU - Michalski, Jeff
AU - Raben, Adam
AU - Rudoler, Shari
AU - Jones, Christopher U.
AU - Sandler, Howard
N1 - Funding Information:
Sources of support: This project was supported by grants U10CA21661 , U10CA180868 , and U10CA180822 from the National Cancer Institute and was funded in part by a grant from the Pennsylvania Department of Health . The Department specifically declaims responsibility for any analyses, interpretations, and conclusions. Publication of this article was funded in part by the University of Florida Open Access Publishing Fund.
Publisher Copyright:
© 2017 The Authors
PY - 2017/10
Y1 - 2017/10
N2 - Objectives We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm. Results Of 2028 patients enrolled, 992 patients were randomized to receive RT alone and 917 (92.4%) had baseline ST values available and completed RT. Of these 917 patients, immediate and 3-month post-RT testosterone levels were available for 447 and 373 patients, respectively. Excluding 2 patients who received hormonal therapy off protocol after RT, 447 and 371 patients, respectively, were analyzed. For all patients, the median change in ST values at completion of RT and at 3-month follow-up were −30.0 ng/dL (p5-p95; −270.0 to 162.0; P <.001) and −34.0 ng/dL (p5-p95, −228.0 to 160.0; P <.01), respectively. Conclusion RT for prostate cancer was associated with a median 9.2% decline in ST at completion of RT and a median 9.3% decline 3 months after RT. These changes were statistically significant.
AB - Objectives We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm. Results Of 2028 patients enrolled, 992 patients were randomized to receive RT alone and 917 (92.4%) had baseline ST values available and completed RT. Of these 917 patients, immediate and 3-month post-RT testosterone levels were available for 447 and 373 patients, respectively. Excluding 2 patients who received hormonal therapy off protocol after RT, 447 and 371 patients, respectively, were analyzed. For all patients, the median change in ST values at completion of RT and at 3-month follow-up were −30.0 ng/dL (p5-p95; −270.0 to 162.0; P <.001) and −34.0 ng/dL (p5-p95, −228.0 to 160.0; P <.01), respectively. Conclusion RT for prostate cancer was associated with a median 9.2% decline in ST at completion of RT and a median 9.3% decline 3 months after RT. These changes were statistically significant.
UR - http://www.scopus.com/inward/record.url?scp=85029547631&partnerID=8YFLogxK
U2 - 10.1016/j.adro.2017.07.004
DO - 10.1016/j.adro.2017.07.004
M3 - Article
C2 - 29204528
AN - SCOPUS:85029547631
SN - 2452-1094
VL - 2
SP - 608
EP - 614
JO - Advances in Radiation Oncology
JF - Advances in Radiation Oncology
IS - 4
ER -