TY - JOUR
T1 - Serum markers in germ cell neoplasms
AU - Bartlett, N. L.
AU - Freiha, F. S.
AU - Torti, F. M.
PY - 1991
Y1 - 1991
N2 - Development of highly sensitive radioimmunoassays for alphafetoprotein and the beta subunit of human chorionic gonadotropin has significantly improved the evaluation, treatment, and monitoring of patients with germ cell neoplasms. Elevated serum tumor markers provide prognostic information at diagnosis, indicate persistent disease following orchiectomy or retroperitoneal lymphadenectomy, and signal a recurrence after chemotherapy. Determination of the optimal duration of chemotherapy is greatly aided by serum markers. Other serum markers, including LDH and PLAP, are occasionally useful for monitoring patients, particularly those with seminoma.
AB - Development of highly sensitive radioimmunoassays for alphafetoprotein and the beta subunit of human chorionic gonadotropin has significantly improved the evaluation, treatment, and monitoring of patients with germ cell neoplasms. Elevated serum tumor markers provide prognostic information at diagnosis, indicate persistent disease following orchiectomy or retroperitoneal lymphadenectomy, and signal a recurrence after chemotherapy. Determination of the optimal duration of chemotherapy is greatly aided by serum markers. Other serum markers, including LDH and PLAP, are occasionally useful for monitoring patients, particularly those with seminoma.
UR - http://www.scopus.com/inward/record.url?scp=0025876205&partnerID=8YFLogxK
U2 - 10.1016/s0889-8588(18)30382-4
DO - 10.1016/s0889-8588(18)30382-4
M3 - Review article
C2 - 1723408
AN - SCOPUS:0025876205
VL - 5
SP - 1245
EP - 1260
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 6
ER -