Serum markers in germ cell neoplasms

N. L. Bartlett, F. S. Freiha, F. M. Torti

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Development of highly sensitive radioimmunoassays for alphafetoprotein and the beta subunit of human chorionic gonadotropin has significantly improved the evaluation, treatment, and monitoring of patients with germ cell neoplasms. Elevated serum tumor markers provide prognostic information at diagnosis, indicate persistent disease following orchiectomy or retroperitoneal lymphadenectomy, and signal a recurrence after chemotherapy. Determination of the optimal duration of chemotherapy is greatly aided by serum markers. Other serum markers, including LDH and PLAP, are occasionally useful for monitoring patients, particularly those with seminoma.

Original languageEnglish
Pages (from-to)1245-1260
Number of pages16
JournalHematology/Oncology Clinics of North America
Issue number6
StatePublished - 1991


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