TY - JOUR
T1 - Serum concentration of 25-hydroxyvitamin D in rickets of extremely premature infants
AU - Hoff, Nancy
AU - Haddad, John
AU - Teitelbaum, Steven
AU - McAlister, William
AU - Hillman, Laura S.
N1 - Funding Information:
From the Department of Pediatrics, Radiology, and Medicine, Washington University School of Medicine and the Division of Neonatology, St. Louis Children's Hospital and the Division of Metabolism, Jewish Hospital of St. Louis. Dr. Haddad supported by National Institutes of Health grant AM 14570-8. Dr. Teitelbaum supported by National Institutes of Health grant AM 11674-1L Dr. Hillman supported by National Institutes of Health grant HD 09998. *Reprint address: St. Louis Children's Hospital, 500 S. Kingshighway. P. O. Box 14871, St. Louis, MO 63178.
PY - 1979/3
Y1 - 1979/3
N2 - Nine premature infants developed radiographic and biochemical rickets at a mean ±SD of 12.6±2.8 weeks of age. Serum 25-hydroxyvitamin D concentrations were all low, with a mean of <3.6±2.1 ng/ml. The mean average daily intake of vitamin D since birth had been 300±181 IU, and the mean average daily intake during the week of diagnosis was 587±313 IU. All of the infants were extremely premature (mean weight 948±153 gm, mean gestation 27.7±1.1 weeks), and were being fed either a low-calcium "human milk-like" formula or a soy formula. It is postulated that low-calcium intake may have increased 25-OHD utilization in the face of a decreased ability of the extremely premature infant to produce 25-OHD. Because of multiple factors leading to both decreased production and possible increased utilization of 25-OHD, such infants have an increased requirement for vitamin D to maintain normal serum 25-OHD concentrations, and daily intakes of at least 400 IU vitamin D orally must be assured. Serum 25-OHD measurements and radiographs may be important in following infnats at risk.
AB - Nine premature infants developed radiographic and biochemical rickets at a mean ±SD of 12.6±2.8 weeks of age. Serum 25-hydroxyvitamin D concentrations were all low, with a mean of <3.6±2.1 ng/ml. The mean average daily intake of vitamin D since birth had been 300±181 IU, and the mean average daily intake during the week of diagnosis was 587±313 IU. All of the infants were extremely premature (mean weight 948±153 gm, mean gestation 27.7±1.1 weeks), and were being fed either a low-calcium "human milk-like" formula or a soy formula. It is postulated that low-calcium intake may have increased 25-OHD utilization in the face of a decreased ability of the extremely premature infant to produce 25-OHD. Because of multiple factors leading to both decreased production and possible increased utilization of 25-OHD, such infants have an increased requirement for vitamin D to maintain normal serum 25-OHD concentrations, and daily intakes of at least 400 IU vitamin D orally must be assured. Serum 25-OHD measurements and radiographs may be important in following infnats at risk.
UR - http://www.scopus.com/inward/record.url?scp=0018372606&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(79)80602-2
DO - 10.1016/S0022-3476(79)80602-2
M3 - Article
C2 - 423037
AN - SCOPUS:0018372606
SN - 0022-3476
VL - 94
SP - 460
EP - 466
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 3
ER -