Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease

Wahid Abu-Amer; Khaled Shorbaji; Rodrigo Meade; Sophia R. Pyeatte; Larisa Belaygorod; Mohamed S. Zaghloul; Shahab Hafezi; Louai Alrata; Amanda Penrose; Batool Arif; Stephen G. Wu; Clay F. Semenkovich; Mohamed A. Zayed

doi:10.1016/j.jacbts.2025.101411

Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease

Wahid Abu-Amer
, Khaled Shorbaji
, Rodrigo Meade
, Sophia R. Pyeatte
, Larisa Belaygorod
, Mohamed S. Zaghloul
, Shahab Hafezi
, Louai Alrata
, Amanda Penrose
, Batool Arif
, Stephen G. Wu
, Clay F. Semenkovich
, Mohamed A. Zayed

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

There are currently no reliable serum biomarkers to aid in the diagnosis of peripheral artery disease (PAD). We hypothesized that circulating fatty acid synthase (cFAS) can be an independent diagnostic biomarker for PAD. Serum cFAS and demographics were compared for patients with and without PAD or chronic limb threatening ischemia (CLTI). Patients with PAD or CLTI had significantly higher serum cFAS content. We observed optimal cutoffs for cFAS in distinguishing between individuals with and without PAD or CLTI. Our study demonstrates that cFAS is an independent serum-based diagnostic biomarker for PAD, can distinguish between patients with PAD vs CLTI, and may predict disease severity.

Original language	English
Article number	101411
Journal	JACC: Basic to Translational Science
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/j.jacbts.2025.101411
State	Published - Dec 2025

Keywords

chronic limb threatening ischemia
diabetes
peripheral artery disease
serum biomarker

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10.1016/j.jacbts.2025.101411

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Abu-Amer, W., Shorbaji, K., Meade, R., Pyeatte, S. R., Belaygorod, L., Zaghloul, M. S., Hafezi, S., Alrata, L., Penrose, A., Arif, B., Wu, S. G., Semenkovich, C. F., & Zayed, M. A. (2025). Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease. JACC: Basic to Translational Science, 10(12), Article 101411. https://doi.org/10.1016/j.jacbts.2025.101411

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title = "Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease",

abstract = "There are currently no reliable serum biomarkers to aid in the diagnosis of peripheral artery disease (PAD). We hypothesized that circulating fatty acid synthase (cFAS) can be an independent diagnostic biomarker for PAD. Serum cFAS and demographics were compared for patients with and without PAD or chronic limb threatening ischemia (CLTI). Patients with PAD or CLTI had significantly higher serum cFAS content. We observed optimal cutoffs for cFAS in distinguishing between individuals with and without PAD or CLTI. Our study demonstrates that cFAS is an independent serum-based diagnostic biomarker for PAD, can distinguish between patients with PAD vs CLTI, and may predict disease severity.",

keywords = "chronic limb threatening ischemia, diabetes, peripheral artery disease, serum biomarker",

author = "Wahid Abu-Amer and Khaled Shorbaji and Rodrigo Meade and Pyeatte, \{Sophia R.\} and Larisa Belaygorod and Zaghloul, \{Mohamed S.\} and Shahab Hafezi and Louai Alrata and Amanda Penrose and Batool Arif and Wu, \{Stephen G.\} and Semenkovich, \{Clay F.\} and Zayed, \{Mohamed A.\}",

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year = "2025",

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doi = "10.1016/j.jacbts.2025.101411",

language = "English",

volume = "10",

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AU - Abu-Amer, Wahid

AU - Shorbaji, Khaled

AU - Meade, Rodrigo

AU - Pyeatte, Sophia R.

AU - Belaygorod, Larisa

AU - Zaghloul, Mohamed S.

AU - Hafezi, Shahab

AU - Alrata, Louai

AU - Penrose, Amanda

AU - Arif, Batool

AU - Wu, Stephen G.

AU - Semenkovich, Clay F.

AU - Zayed, Mohamed A.

PY - 2025/12

Y1 - 2025/12

N2 - There are currently no reliable serum biomarkers to aid in the diagnosis of peripheral artery disease (PAD). We hypothesized that circulating fatty acid synthase (cFAS) can be an independent diagnostic biomarker for PAD. Serum cFAS and demographics were compared for patients with and without PAD or chronic limb threatening ischemia (CLTI). Patients with PAD or CLTI had significantly higher serum cFAS content. We observed optimal cutoffs for cFAS in distinguishing between individuals with and without PAD or CLTI. Our study demonstrates that cFAS is an independent serum-based diagnostic biomarker for PAD, can distinguish between patients with PAD vs CLTI, and may predict disease severity.

AB - There are currently no reliable serum biomarkers to aid in the diagnosis of peripheral artery disease (PAD). We hypothesized that circulating fatty acid synthase (cFAS) can be an independent diagnostic biomarker for PAD. Serum cFAS and demographics were compared for patients with and without PAD or chronic limb threatening ischemia (CLTI). Patients with PAD or CLTI had significantly higher serum cFAS content. We observed optimal cutoffs for cFAS in distinguishing between individuals with and without PAD or CLTI. Our study demonstrates that cFAS is an independent serum-based diagnostic biomarker for PAD, can distinguish between patients with PAD vs CLTI, and may predict disease severity.

KW - chronic limb threatening ischemia

KW - diabetes

KW - peripheral artery disease

KW - serum biomarker

UR - https://www.scopus.com/pages/publications/105022643550

U2 - 10.1016/j.jacbts.2025.101411

DO - 10.1016/j.jacbts.2025.101411

M3 - Article

C2 - 41232174

AN - SCOPUS:105022643550

SN - 2452-302X

VL - 10

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 12

M1 - 101411

ER -

Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease

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Keywords

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