Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Jieya Shao

doi:10.1080/23723556.2020.1796179

Ser⁷⁸⁴ phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Jieya Shao

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser⁷⁸⁴ phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.

Original language	English
Article number	1796179
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2020.1796179
State	Published - Sep 2 2020

Keywords

DNA damage response
Proteostasis
chemotherapy
phosphorylation
prognostic biomarker

Access to Document

10.1080/23723556.2020.1796179

Cite this

@article{d526664afe054963a54e7a01f37a7686,

title = "Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response",

abstract = "Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.",

keywords = "DNA damage response, Proteostasis, chemotherapy, phosphorylation, prognostic biomarker",

author = "Jieya Shao",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2020",

month = sep,

day = "2",

doi = "10.1080/23723556.2020.1796179",

language = "English",

volume = "7",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

number = "5",

}

TY - JOUR

T1 - Ser784 phosphorylation

T2 - a clinically relevant enhancer of VCP function in the DNA damage response

AU - Shao, Jieya

PY - 2020/9/2

Y1 - 2020/9/2

N2 - Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.

AB - Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.

KW - DNA damage response

KW - Proteostasis

KW - chemotherapy

KW - phosphorylation

KW - prognostic biomarker

UR - https://www.scopus.com/pages/publications/85089448438

U2 - 10.1080/23723556.2020.1796179

DO - 10.1080/23723556.2020.1796179

M3 - Comment/debate

C2 - 32944647

AN - SCOPUS:85089448438

SN - 2372-3556

VL - 7

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 5

M1 - 1796179

ER -

Ser⁷⁸⁴ phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this