TY - JOUR
T1 - Ser784 phosphorylation
T2 - a clinically relevant enhancer of VCP function in the DNA damage response
AU - Shao, Jieya
N1 - Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2020/9/2
Y1 - 2020/9/2
N2 - Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.
AB - Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.
KW - DNA damage response
KW - Proteostasis
KW - chemotherapy
KW - phosphorylation
KW - prognostic biomarker
UR - http://www.scopus.com/inward/record.url?scp=85089448438&partnerID=8YFLogxK
U2 - 10.1080/23723556.2020.1796179
DO - 10.1080/23723556.2020.1796179
M3 - Comment/debate
C2 - 32944647
AN - SCOPUS:85089448438
SN - 2372-3556
VL - 7
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 5
M1 - 1796179
ER -