Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.

Original languageEnglish
Article number1796179
JournalMolecular and Cellular Oncology
Volume7
Issue number5
DOIs
StatePublished - Sep 2 2020

Keywords

  • DNA damage response
  • Proteostasis
  • chemotherapy
  • phosphorylation
  • prognostic biomarker

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