Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA

Brittany K. Smith, Andrew B. Janowski, Jonathan E. Danis, Ian B. Harvey, Haiyan Zhao, Ya Nan Dai, Christopher W. Farnsworth, Ann M. Gronowski, Stephen Roper, Daved H. Fremont, David Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Reported coronavirus disease 2019 (COVID-19) case counts likely underestimate the true prevalence because mild or asymptomatic cases often go untested. Here, we use a sero-survey to estimate the seroprevalence of IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the St. Louis, MO, metropolitan area in a symptom-independent manner. Five hundred three adult and 555 pediatric serum/plasma samples were collected from patients presenting to Barnes-Jewish Hospital or St. Louis Children’s Hospital between 14 April 2020 and 12 May 2020. We developed protocols for in-house enzyme-linked immunosorbent assays (ELISAs) using spike and nucleoprotein and used the assays to estimate a seroprevalence rate based on our samples. Overall IgG seropositivity was estimated to be 1.71% (95% credible interval [CI], 0.04% to 3.38%) in pediatric samples and 3.11% (95% CI, 0.92% to 5.32%) in adult samples. Seropositivity was significantly lower in children under 5 years of age than in adults, but rates between adults and children aged 5 or older were similar. Of the 176 samples tested from children under 4 years of age, none were positive.

Original languageEnglish
Article numbere01207-20
Pages (from-to)1-7
Number of pages7
JournalmSphere
Volume6
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • St. Louis
  • serology
  • seroprevalence

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