Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

R. A. Khan, R. D. Chernock, J. S. Lewis

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The sinonasal tract is a complex anatomic site, home to a wide variety of reactive, inflammatory, benign, and malignant lesions. Inflammatory polyps and papillomas are usually easily recognized by pathologists. A poorly understood lesion that has been more clearly defined in recent years is the nasal hamartoma. The epithelial subtypes include seromucinous hamartoma, respiratory epithelial adenomatoid hamartoma, and hybrid lesions. Seromucinous hamartomas have only been recognized and substantially reported over the past few years. They are a diagnostic challenge, needing to be distinguished from low grade adenocarcinomas, and are of interest because most of the basic questions about their pathophysiology remain unanswered. Herein, we present two novel cases of seromucinous hamartoma with features that partly expand the morphologic spectrum of these lesions, discuss the differential diagnosis, and review the literature to compare our findings with previously reported cases with the aim of better understanding this interesting entity.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalHead and Neck Pathology
Issue number3
StatePublished - Sep 2011


  • Low grade adenocarcinoma
  • Microglandular adenosis
  • Nasal cavity
  • Respiratory epithelial adenomatoid hamartoma
  • Seromucinous hamartoma


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