Serological evidence of human klassevirus infection

Alexander L. Greninger, Lori Holtz, Gagandeep Kang, Donald Ganem, David Wang, Joseph L. DeRisi

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.

Original languageEnglish
Pages (from-to)1584-1588
Number of pages5
JournalClinical and Vaccine Immunology
Issue number10
StatePublished - Oct 2010


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