@article{584f95fa2ab74518bc67ce45f6777ad5,
title = "Serologic responses to COVID-19 vaccination in children with history of multisystem inflammatory syndrome (MIS-C)",
abstract = "Understanding the serological responses to COVID-19 vaccination in children with history of MIS-C could inform vaccination recommendations. We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. We found that SARS-CoV-2 variant cross-reactive IgG antibodies variably waned following acute MIS-C, but were significantly boosted with vaccination and maintained for up to 3 months. We then compared post-vaccination binding, pseudovirus neutralizing, and functional antibody-dependent cell-mediated cytotoxicity (ADCC) titers to the reference strain (Wuhan-hu-1) and Omicron variant (B.1.1.529) among previously healthy children (n = 16) and children with history of MIS-C (n = 7) or COVID-19 (n = 8). Despite the breadth of binding antibodies elicited by vaccination in all three groups, pseudovirus neutralizing and ADCC titers were significantly reduced to the Omicron variant.",
author = "Perez, {Maria A.} and Hsiao, {Hui Mien} and Xuemin Chen and Amber Kunkel and Nadine Baida and Laila Hussaini and Lu, {Austin T.} and Kao, {Carol M.} and Laham, {Federico R.} and Hunstad, {David A.} and Yajira Beltran and Hammett, {Teresa A.} and Shana Godfred-Cato and Ann Chahroudi and Anderson, {Evan J.} and Ermias Belay and Rostad, {Christina A.}",
note = "Funding Information: This work was funded by Emory University and Children{\textquoteright}s Healthcare of Atlanta, and by the U.S. Centers for Disease Control and Prevention. Funding Information: E.J.A. has consulted for Pfizer, Sanofi Pasteur, Janssen, GSK, and Medscape, and his institution receives funds to conduct clinical research unrelated to this manuscript from MedImmune, Regeneron, PaxVax, Pfizer, GSK, Merck, Sanonfi-Pasteur, Janssen, and Micron. He also serves on data and safety monitoring boards for Kentucky BioProcessing, Inc., and Sanofi-Pasteur. He serves on a data adjudication board for WCG and ACI Clinical. His institution has also received funding from NIH to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = apr,
day = "24",
doi = "10.1016/j.vaccine.2023.03.021",
language = "English",
volume = "41",
pages = "2743--2748",
journal = "Vaccine",
issn = "0264-410X",
number = "17",
}