TY - JOUR
T1 - Serious pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus
T2 - A case-control study
AU - Fichtenbaum, Carl J.
AU - Woeltje, Keith F.
AU - Powderly, William G.
N1 - Funding Information:
Received 6 December 1993; revised 14 February 1994. Grant support: This study was supported in part by the National Institutes of Health (grant #AI25903) and U.S. Public Health Service (grant #DA0726 1-0 I). Reprints or correspondence: Dr. Carl J. Fichtenbaurn. Department of Internal Medicine. Division of Infectious Diseases. Washington University School of Medicine. Box 80 I I. 660 South Euclid Avenue. St. Louis. Missouri 63\ 10.
PY - 1994/9
Y1 - 1994/9
N2 - We conducted a case-control study to determine the incidence and clinical features of and risk factors for Pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus (HIV). Twenty-five patients who had 37 episodes of P. aeruginosa infection from 1990 through 1992 were identified. Most of the patients (92%) were homosexual men with low CD4+ lymphocyte counts and a history of AIDS. The annual incidence rates of P. aeruginosa infection were 3.5% (1990), 6.3% (1991), and 8.7% (1992). Most infections were community-acquired (68%) and involved the respiratory tract (73%). Patients were more likely than HIV-infected controls to have AIDS and had more AIDS-defining opportunistic illnesses. The overall mortality was 36%. Recurrent episodes were common (39%). We conclude that P. aeruginosa infections may be an increasing problem in patients with extremely advanced HIV infection. Clinicians should consider including antibiotics with activity against P. aeruginosa in the empirical treatment for suspected bacterial infection in patients with advanced HIV infection.
AB - We conducted a case-control study to determine the incidence and clinical features of and risk factors for Pseudomonas aeruginosa infections in patients infected with human immunodeficiency virus (HIV). Twenty-five patients who had 37 episodes of P. aeruginosa infection from 1990 through 1992 were identified. Most of the patients (92%) were homosexual men with low CD4+ lymphocyte counts and a history of AIDS. The annual incidence rates of P. aeruginosa infection were 3.5% (1990), 6.3% (1991), and 8.7% (1992). Most infections were community-acquired (68%) and involved the respiratory tract (73%). Patients were more likely than HIV-infected controls to have AIDS and had more AIDS-defining opportunistic illnesses. The overall mortality was 36%. Recurrent episodes were common (39%). We conclude that P. aeruginosa infections may be an increasing problem in patients with extremely advanced HIV infection. Clinicians should consider including antibiotics with activity against P. aeruginosa in the empirical treatment for suspected bacterial infection in patients with advanced HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=0028145501&partnerID=8YFLogxK
U2 - 10.1093/clinids/19.3.417
DO - 10.1093/clinids/19.3.417
M3 - Article
C2 - 7811859
AN - SCOPUS:0028145501
SN - 1058-4838
VL - 19
SP - 417
EP - 422
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -