TY - JOUR
T1 - Serial serum 25-Hydroxyvitamin D and mineral homeostasis in very premature infants fed preterm human milk
AU - Hillman, Laura S.
AU - Salmons, Sharon J.
AU - Slatopolsky, Eduardo
AU - McAlister, William H.
PY - 1985/10
Y1 - 1985/10
N2 - Fourteen very low birthweight infants (mean ± SD 1,070 ± 180 g and 29.3 ± 1.9 weeks gestation) fed their own mother’s milk were clinically followed until 3-4 months of age with frequent measurements of serum calcium, phosphorus, magnesium, 25-hydroxyvitamin D (25-OHD), parathyroid hormone, alkaline phosphatase, and albumin, and urine calcium, phosphorus, and magnesium. These infants were matched for birthweight and gestation with 14 infants (1,075 ± 152 g and 29.0 ± 1.7 weeks) who had been similarly followed during concomitant studies of infants fed standard formula (Similac 20 cal/oz). Urine phosphorus was markedly lower in the breast milk-fed group from initiation of feedings, and serum phosphorus became significantly lower at and after 6 weeks of age. The fall in serum phosphorus was accompanied by a marked calciuria. Parathyroid hormone was suppressed in the breast milk-fed group, although serum calcium was not elevated and did not differ from formula-fed infants. A high incidence of moderate-severe hypomineralization on radiographs was seen in both breast milk-and formula-fed groups. Six of 14 breast-fed infants required phosphorus supplementation at 8-10 weeks of age because of significant hypophosphatemia, hypercalciuria, and hypomineralization. These infants differed from those not requiring phosphorus supplements by being smaller at birth but not of lower gestation, and having persistently low serum 25-OHD at and after 6 weeks of age.
AB - Fourteen very low birthweight infants (mean ± SD 1,070 ± 180 g and 29.3 ± 1.9 weeks gestation) fed their own mother’s milk were clinically followed until 3-4 months of age with frequent measurements of serum calcium, phosphorus, magnesium, 25-hydroxyvitamin D (25-OHD), parathyroid hormone, alkaline phosphatase, and albumin, and urine calcium, phosphorus, and magnesium. These infants were matched for birthweight and gestation with 14 infants (1,075 ± 152 g and 29.0 ± 1.7 weeks) who had been similarly followed during concomitant studies of infants fed standard formula (Similac 20 cal/oz). Urine phosphorus was markedly lower in the breast milk-fed group from initiation of feedings, and serum phosphorus became significantly lower at and after 6 weeks of age. The fall in serum phosphorus was accompanied by a marked calciuria. Parathyroid hormone was suppressed in the breast milk-fed group, although serum calcium was not elevated and did not differ from formula-fed infants. A high incidence of moderate-severe hypomineralization on radiographs was seen in both breast milk-and formula-fed groups. Six of 14 breast-fed infants required phosphorus supplementation at 8-10 weeks of age because of significant hypophosphatemia, hypercalciuria, and hypomineralization. These infants differed from those not requiring phosphorus supplements by being smaller at birth but not of lower gestation, and having persistently low serum 25-OHD at and after 6 weeks of age.
KW - 25-Hydroxyvitamin D
KW - Breast milk
KW - Extreme prematurity
KW - Phosphorus
UR - http://www.scopus.com/inward/record.url?scp=0021843185&partnerID=8YFLogxK
U2 - 10.1097/00005176-198510000-00014
DO - 10.1097/00005176-198510000-00014
M3 - Article
C2 - 3876419
AN - SCOPUS:0021843185
VL - 4
SP - 762
EP - 770
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 5
ER -