Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hongliang Hu, Matthew J. Hilton, Xiaolin Tu, Kai Yu, David M. Ornitz, Fanxin Long

Research output: Contribution to journalArticlepeer-review

548 Scopus citations

Abstract

Signals that govern development of the osteoblast lineage are not well understood. Indian hedgehog (Ihh), a member of the hedgehog (Hh) family of proteins, is essential for osteogenesis in the endochondral skeleton during embryogenesis. The canonical pathway of Wnt signaling has been implicated by studies of Lrp5, a co-receptor for Wnt proteins, in postnatal bone mass homeostasis. In the present study we demonstrate that β-catenin, a central player in the canonical Wnt pathway, is indispensable for osteoblast differentiation in the mouse embryo. Moreover, we present evidence that Wnt signaling functions downstream of Ihh in development of the osteoblast lineage. Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalDevelopment
Volume132
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Hh
  • Mouse
  • Osteoblast
  • Wnt

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