Sequential and opposing alterations of 5-HT 1A receptor function during withdrawal from chronic morphine

Pierre Eric Lutz; Amynah A. Pradhan; Celia Goeldner; Brigitte L. Kieffer

doi:10.1016/j.euroneuro.2011.02.002

Sequential and opposing alterations of 5-HT _1A receptor function during withdrawal from chronic morphine

Pierre Eric Lutz, Amynah A. Pradhan, Celia Goeldner, Brigitte L. Kieffer

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT _1A receptor crucially regulate emotional behaviors both in humans and rodents. Using [ ³⁵S]GTPγS autoradiography in mice, we show that 5-HT _1A receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.

Original language	English
Pages (from-to)	835-840
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	21
Issue number	11
DOIs	https://doi.org/10.1016/j.euroneuro.2011.02.002
State	Published - Nov 2011

Keywords

5-HT receptor
Addiction
Autoradiography
Dorsal raphe nucleus
Medial prefrontal cortex
Mouse

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10.1016/j.euroneuro.2011.02.002

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title = "Sequential and opposing alterations of 5-HT 1A receptor function during withdrawal from chronic morphine",

abstract = "Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT 1A receptor crucially regulate emotional behaviors both in humans and rodents. Using [ 35S]GTPγS autoradiography in mice, we show that 5-HT 1A receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.",

keywords = "5-HT receptor, Addiction, Autoradiography, Dorsal raphe nucleus, Medial prefrontal cortex, Mouse",

author = "Lutz, {Pierre Eric} and Pradhan, {Amynah A.} and Celia Goeldner and Kieffer, {Brigitte L.}",

note = "Funding Information: This work was supported by the Centre National de la Recherche Scientifique, Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale, Universit{\'e} de Strasbourg and the National Institute of Health ((NIAAA AA-16658 and NIDA DA-16768). Funding agencies had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",

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AU - Goeldner, Celia

AU - Kieffer, Brigitte L.

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AB - Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT 1A receptor crucially regulate emotional behaviors both in humans and rodents. Using [ 35S]GTPγS autoradiography in mice, we show that 5-HT 1A receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.

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KW - Autoradiography

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KW - Medial prefrontal cortex

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Sequential and opposing alterations of 5-HT _1A receptor function during withdrawal from chronic morphine

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Keywords

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