Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors

Emma E. Thompson; Gabe Haller; Jayant M. Pinto; Ying Sun; Bethanne Zelano; Suma Jacob; Martha K. McClintock; Dan L. Nicolae; Carole Ober

doi:10.1016/j.humimm.2009.10.004

Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors

Emma E. Thompson, Gabe Haller, Jayant M. Pinto, Ying Sun, Bethanne Zelano, Suma Jacob, Martha K. McClintock, Dan L. Nicolae, Carole Ober

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9 Scopus citations

Abstract

We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.

Original language	English
Pages (from-to)	100-103
Number of pages	4
Journal	Human Immunology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2009.10.004
State	Published - Jan 2010

Keywords

HLA alleles
Linkage disequilibrium
Olfactory receptor genes
Smell preferences

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10.1016/j.humimm.2009.10.004

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title = "Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors",

abstract = "We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.",

keywords = "HLA alleles, Linkage disequilibrium, Olfactory receptor genes, Smell preferences",

author = "Thompson, {Emma E.} and Gabe Haller and Pinto, {Jayant M.} and Ying Sun and Bethanne Zelano and Suma Jacob and McClintock, {Martha K.} and Nicolae, {Dan L.} and Carole Ober",

note = "Funding Information: The authors thank Yoav Gilad for primer design and helpful discussions regarding the manuscript. This work was supported by grants from the National Institutes of Health ( HD21244 , to C.O.) and T32 HL007605 (to E.E.T.) and by a Dennis W. Jahnigen/American Geriatrics Society fellowship (to J.M.P.). ",

year = "2010",

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doi = "10.1016/j.humimm.2009.10.004",

language = "English",

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AU - Thompson, Emma E.

AU - Haller, Gabe

AU - Pinto, Jayant M.

AU - Sun, Ying

AU - Zelano, Bethanne

AU - Jacob, Suma

AU - McClintock, Martha K.

AU - Nicolae, Dan L.

AU - Ober, Carole

N1 - Funding Information: The authors thank Yoav Gilad for primer design and helpful discussions regarding the manuscript. This work was supported by grants from the National Institutes of Health ( HD21244 , to C.O.) and T32 HL007605 (to E.E.T.) and by a Dennis W. Jahnigen/American Geriatrics Society fellowship (to J.M.P.).

PY - 2010/1

Y1 - 2010/1

N2 - We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.

AB - We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.

KW - HLA alleles

KW - Linkage disequilibrium

KW - Olfactory receptor genes

KW - Smell preferences

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Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors

Abstract

Keywords

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