Sequence of the human factor VIII-associated gene is conserved in mouse

Barbara Levinson, John R. Bermingham, Aida Metzenberg, Susan Kenwrick, Verne Chapman, Jane Gitschier

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


cDNA and genomic clones corresponding to the human factor VIII-associated gene (F8A) were isolated from mouse cDNA and F8A-enriched genomic libraries. The sequences of these clones revealed an intronless gene conding for 380 amino acids, with 85% identity the predicted human sequence. The single murine gene copy is genetically linked to factor VIII, but appears to lie outside the factor VIII gene by physical mapping. Like the human gene, the mouse F8A gene is highly expressed in a wide variety of tissues. This evolutionary comparison has helped to clarify the derived amino acid sequence in the human and strongly supports the hypothesis that the F8A gene encodes a protein.

Original languageEnglish
Pages (from-to)862-865
Number of pages4
Issue number3
StatePublished - Jul 1992


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