Sequence of the gene for the constant region of the μ chain of Balb/c mouse immunoglobulin

Gregory I. Goldberg; Elio F. Vanin; Alexander M. Zrolka; Frederick R. Blattner

doi:10.1016/0378-1119(81)90102-5

Sequence of the gene for the constant region of the μ chain of Balb/c mouse immunoglobulin

Gregory I. Goldberg
, Elio F. Vanin
, Alexander M. Zrolka
, Frederick R. Blattner

Division of Dermatology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We present the complete sequence of Cμ immunoglobulin constant region gene of mouse with 5′ flanking and 3′ untranslated regions. The gene consists of four exons coding for protein domains which are separated by three introns. Intensive study of the homology relationship of DNA sequences within the Cμ gene and Cγ2b gene leads us to believe that the shifting of existing splice sites along with creation of new ones plays a significant role in evolution, driving the reversible reaction exon {left arrow, hooked} intron.

Original language	English
Pages (from-to)	33-42
Number of pages	10
Journal	Gene
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0378-1119(81)90102-5
State	Published - Oct 1981

Keywords

Nucleotide sequence
computer analysis of nucleotide sequence
immunoglobulin genes
molecular evolution

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10.1016/0378-1119(81)90102-5

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abstract = "We present the complete sequence of Cμ immunoglobulin constant region gene of mouse with 5′ flanking and 3′ untranslated regions. The gene consists of four exons coding for protein domains which are separated by three introns. Intensive study of the homology relationship of DNA sequences within the Cμ gene and Cγ2b gene leads us to believe that the shifting of existing splice sites along with creation of new ones plays a significant role in evolution, driving the reversible reaction exon \{left arrow, hooked\} intron.",

keywords = "Nucleotide sequence, computer analysis of nucleotide sequence, immunoglobulin genes, molecular evolution",

author = "Goldberg, \{Gregory I.\} and Vanin, \{Elio F.\} and Zrolka, \{Alexander M.\} and Blattner, \{Frederick R.\}",

year = "1981",

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AU - Goldberg, Gregory I.

AU - Vanin, Elio F.

AU - Zrolka, Alexander M.

AU - Blattner, Frederick R.

PY - 1981/10

Y1 - 1981/10

N2 - We present the complete sequence of Cμ immunoglobulin constant region gene of mouse with 5′ flanking and 3′ untranslated regions. The gene consists of four exons coding for protein domains which are separated by three introns. Intensive study of the homology relationship of DNA sequences within the Cμ gene and Cγ2b gene leads us to believe that the shifting of existing splice sites along with creation of new ones plays a significant role in evolution, driving the reversible reaction exon {left arrow, hooked} intron.

AB - We present the complete sequence of Cμ immunoglobulin constant region gene of mouse with 5′ flanking and 3′ untranslated regions. The gene consists of four exons coding for protein domains which are separated by three introns. Intensive study of the homology relationship of DNA sequences within the Cμ gene and Cγ2b gene leads us to believe that the shifting of existing splice sites along with creation of new ones plays a significant role in evolution, driving the reversible reaction exon {left arrow, hooked} intron.

KW - Nucleotide sequence

KW - computer analysis of nucleotide sequence

KW - immunoglobulin genes

KW - molecular evolution

UR - https://www.scopus.com/pages/publications/0019819211

U2 - 10.1016/0378-1119(81)90102-5

DO - 10.1016/0378-1119(81)90102-5

M3 - Article

C2 - 6795090

AN - SCOPUS:0019819211

SN - 0378-1119

VL - 15

SP - 33

EP - 42

JO - Gene

JF - Gene

IS - 1

ER -

Sequence of the gene for the constant region of the μ chain of Balb/c mouse immunoglobulin

Abstract

Keywords

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