Sequence of the gene for the constant region of the μ chain of Balb/c mouse immunoglobulin

Gregory I. Goldberg, Elio F. Vanin, Alexander M. Zrolka, Frederick R. Blattner

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

We present the complete sequence of Cμ immunoglobulin constant region gene of mouse with 5′ flanking and 3′ untranslated regions. The gene consists of four exons coding for protein domains which are separated by three introns. Intensive study of the homology relationship of DNA sequences within the Cμ gene and Cγ2b gene leads us to believe that the shifting of existing splice sites along with creation of new ones plays a significant role in evolution, driving the reversible reaction exon {left arrow, hooked} intron.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalGene
Volume15
Issue number1
DOIs
StatePublished - Oct 1981

Keywords

  • Nucleotide sequence
  • computer analysis of nucleotide sequence
  • immunoglobulin genes
  • molecular evolution

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