Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy

Richard S. Hotchkiss, Guillaume Monneret, Didier Payen

Research output: Contribution to journalReview articlepeer-review

1700 Scopus citations


Sepsis-which is a severe life-threatening infection with organ dysfunction-initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro-and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro-and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.

Original languageEnglish
Pages (from-to)862-874
Number of pages13
JournalNature Reviews Immunology
Issue number12
StatePublished - Dec 2013


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