Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

Brian D. Evavold, Paul M. Allen

Research output: Contribution to journalArticlepeer-review

517 Scopus citations

Abstract

In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation. An altered Hb peptide with a single amino acid substitution induced only cytokine secretion and did not induce proliferation. Interleukin-1 costimulated and restored the Th proliferative response to normal levels. The altered peptide also supported cognate T cell-B cell interactions indicative of T cell helper function. Thus, this result suggests that the T cell receptor has the capacity of diffitrential signaling.

Original languageEnglish
Pages (from-to)1308-1310
Number of pages3
JournalScience
Volume252
Issue number5010
DOIs
StatePublished - 1991

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