Sensory TRP channels: The key transducers of nociception and pain

Aaron D. Mickle, Andrew J. Shepherd, Durga P. Mohapatra

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

72 Scopus citations

Abstract

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages73-118
Number of pages46
DOIs
StatePublished - 2015

Publication series

NameProgress in Molecular Biology and Translational Science
Volume131
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • TRP channel Nociception TRPV1 TRPV2 TRPV3 TRPV4 TRPM3 TRPM8 TRPA1 Pain

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