TY - JOUR
T1 - Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders
AU - Hilton, Claudia L.
AU - Babb-Keeble, Alison
AU - Westover, Erin Eitzmann
AU - Zhang, Yi
AU - Adams, Claire
AU - Collins, Diane M.
AU - Karmarkar, Amol
AU - Reistetter, Timothy A.
AU - Constantino, John N.
N1 - Funding Information:
The authors wish to thank the families who participated in this study. They would also like to thank Jessica Essig, Leah Katz, Megan White, Kelly Schwieterman, Sophie Goloff, Laura Madlinger, Lara Oakley, Molly McGrath, and Teddi Gray for their assistance with this project. Funding was provided by Autism Speaks (Grant No. 2036) and Simons Foundation (US).
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.
AB - This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.
KW - Autism
KW - Endophenotype
KW - Family
KW - Genetics
KW - Sensory responsiveness
UR - http://www.scopus.com/inward/record.url?scp=84990866802&partnerID=8YFLogxK
U2 - 10.1007/s10803-016-2918-y
DO - 10.1007/s10803-016-2918-y
M3 - Article
C2 - 27704293
AN - SCOPUS:84990866802
SN - 0162-3257
VL - 46
SP - 3778
EP - 3787
JO - Journal of autism and developmental disorders
JF - Journal of autism and developmental disorders
IS - 12
ER -