Sensory Responsiveness in Siblings of Children with Autism Spectrum Disorders

Claudia L. Hilton, Alison Babb-Keeble, Erin Eitzmann Westover, Yi Zhang, Claire Adams, Diane M. Collins, Amol Karmarkar, Timothy A. Reistetter, John N. Constantino

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


This study examined sensory responsiveness in unaffected siblings of children with autism spectrum disorder (ASD) and associations between sensory responsiveness and social severity. Sensory Profile Caregiver Questionnaires and Social Responsiveness Scales were completed by parents of 185 children between age 4 and 10.95 years. Significant differences were found between participants with ASD and controls, and between participants with ASD and unaffected siblings for all sensory quadrants and domains, but not between controls and unaffected siblings. Social responsiveness scores were significantly correlated with scores from most sensory profile categories. Sensory responsiveness as an endophenotype of ASD is not indicated from these findings; however, studies with larger numbers of unaffected siblings and controls are needed to confirm the null hypothesis.

Original languageEnglish
Pages (from-to)3778-3787
Number of pages10
JournalJournal of autism and developmental disorders
Issue number12
StatePublished - Dec 1 2016


  • Autism
  • Endophenotype
  • Family
  • Genetics
  • Sensory responsiveness


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