TY - JOUR
T1 - Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells
AU - Wang, Peter L.
AU - Czepielewski, Rafael S.
AU - Randolph, Gwendalyn J.
N1 - Funding Information:
Work in the laboratory of G.J.R. is supported by NIH grants R37AI049653 , R01DK119147 , DP1DK126190 , and a Synergy Award from the Rainin Foundation . P.L.W. received support from the Principles in Pulmonary Research training grant ( T32 HL007317-41 ) and R.S.C. received support from the Lawrence C. Pakula, MD IBD Education & Innovation Fund ( FA-2020-01-IBD-1 ).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/3
Y1 - 2021/3
N2 - The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.
AB - The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.
UR - http://www.scopus.com/inward/record.url?scp=85100585221&partnerID=8YFLogxK
U2 - 10.1016/j.it.2021.01.008
DO - 10.1016/j.it.2021.01.008
M3 - Short survey
C2 - 33563563
AN - SCOPUS:85100585221
VL - 42
SP - 180
EP - 182
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 3
ER -