Sensitivity enhancement of NIR fluorescence contrast agent utilizing gold nanoparticles

Kyung A. Kang, Jianting Wang, Martin G. O'Toole, Michael Nantz, Joseph D. Moore, Sebastien Laulhe, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

For optical diagnosis of the human body, using near infrared (NIR) has several advantages: NIR penetrates into the tissue deeper than UV or visible light, and in NIR most of the tissue-originated fluorescence may be avoided. Although NIR fluorophores are valuable, only a few can be used for humans and they have relatively low quantum yields. If the fluorescence emission of NIR fluorophores can be artificially enhanced, it can increase the sensitivity of optical diagnosis. In addition, conditionally emitted contrast agents as in Förster resonance energy transfer (FRET) or molecular beacon can be developed. One way of artificially changing fluorescence is by applying an electric field to the fluorophore. An excellent way of generating the field is via the plasmon field by gold nanoparticles (GNPs) upon the receipt of the excitation light of the fluorophore to be used. In this paper, the mechanism of the fluorescence manipulation for an NIR fluorophore, Cypate, by GNPs is studied both theoretically and experimentally.

Original languageEnglish
Title of host publicationOxygen Transport to Tissue XXXIII
Pages285-291
Number of pages7
DOIs
StatePublished - Feb 1 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume737
ISSN (Print)0065-2598

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