Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques

Dalin Tang; Chun Yang; Jie Zheng; Pamela K. Woodard; Gregorio A. Sicardd; Jeffrey E. Saffitze; Chun Yuan

Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques

Dalin Tang, Chun Yang, Jie Zheng, Pamela K. Woodard, Gregorio A. Sicardd, Jeffrey E. Saffitze, Chun Yuan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Accuracy and reliability are extremely important when computational models are used to analyze biological systems and make diagnostic decisions and clinical predictions. In this paper, sensitivity analysis is performed for magnetic resonance imaging (MRI)-based three-dimensional (3D) models with multi-component plaque structure and fluid- structure interactions (FSI) to quantify effects of various controlling factors on stress/strain distributions in human atherosclerotic coronary and carotid plaques. Our quantitative results indicate that plaque morphology and structure, vessel and plaque material properties, and pressure conditions all have considerable effects on flow and plaque stress/ strain behaviors. This FSI multi-component model provides more complete stress/strain analysis and better interpretation of information from magnetic resonance images and may lead to more accurate plaque vulnerability assessment and rupture predictions.

Original language	English
Title of host publication	3rd M.I.T. Conference on Computational Fluid and Solid Mechanics
Pages	1009-1013
Number of pages	5
State	Published - 2005
Event	3rd M.I.T. Conference on Computational Fluid and Solid Mechanics - Boston, MA, United States Duration: Jun 14 2005 → Jun 17 2005

Publication series

Name	3rd M.I.T. Conference on Computational Fluid and Solid Mechanics

Conference

Conference	3rd M.I.T. Conference on Computational Fluid and Solid Mechanics
Country/Territory	United States
City	Boston, MA
Period	06/14/05 → 06/17/05

Keywords

Artery
Atherosclerotic plaque
Carotid
Coronary
Fluid-structure interactions
MRI

Cite this

Tang, D., Yang, C., Zheng, J., Woodard, P. K., Sicardd, G. A., Saffitze, J. E., & Yuan, C. (2005). Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques. In 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics (pp. 1009-1013). (3rd M.I.T. Conference on Computational Fluid and Solid Mechanics).

@inproceedings{b07b500da5f94db290c4bc36f14b14ba,

title = "Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques",

abstract = "Accuracy and reliability are extremely important when computational models are used to analyze biological systems and make diagnostic decisions and clinical predictions. In this paper, sensitivity analysis is performed for magnetic resonance imaging (MRI)-based three-dimensional (3D) models with multi-component plaque structure and fluid- structure interactions (FSI) to quantify effects of various controlling factors on stress/strain distributions in human atherosclerotic coronary and carotid plaques. Our quantitative results indicate that plaque morphology and structure, vessel and plaque material properties, and pressure conditions all have considerable effects on flow and plaque stress/ strain behaviors. This FSI multi-component model provides more complete stress/strain analysis and better interpretation of information from magnetic resonance images and may lead to more accurate plaque vulnerability assessment and rupture predictions.",

keywords = "Artery, Atherosclerotic plaque, Carotid, Coronary, Fluid-structure interactions, MRI",

author = "Dalin Tang and Chun Yang and Jie Zheng and Woodard, {Pamela K.} and Sicardd, {Gregorio A.} and Saffitze, {Jeffrey E.} and Chun Yuan",

year = "2005",

language = "English",

isbn = "0080444814",

series = "3rd M.I.T. Conference on Computational Fluid and Solid Mechanics",

pages = "1009--1013",

booktitle = "3rd M.I.T. Conference on Computational Fluid and Solid Mechanics",

note = "3rd M.I.T. Conference on Computational Fluid and Solid Mechanics ; Conference date: 14-06-2005 Through 17-06-2005",

}

Tang, D, Yang, C, Zheng, J , Woodard, PK, Sicardd, GA, Saffitze, JE & Yuan, C 2005, Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques. in 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics. 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics, pp. 1009-1013, 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics, Boston, MA, United States, 06/14/05.

Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques. / Tang, Dalin; Yang, Chun; Zheng, Jie et al.
3rd M.I.T. Conference on Computational Fluid and Solid Mechanics. 2005. p. 1009-1013 (3rd M.I.T. Conference on Computational Fluid and Solid Mechanics).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques

AU - Tang, Dalin

AU - Yang, Chun

AU - Zheng, Jie

AU - Woodard, Pamela K.

AU - Sicardd, Gregorio A.

AU - Saffitze, Jeffrey E.

AU - Yuan, Chun

PY - 2005

Y1 - 2005

N2 - Accuracy and reliability are extremely important when computational models are used to analyze biological systems and make diagnostic decisions and clinical predictions. In this paper, sensitivity analysis is performed for magnetic resonance imaging (MRI)-based three-dimensional (3D) models with multi-component plaque structure and fluid- structure interactions (FSI) to quantify effects of various controlling factors on stress/strain distributions in human atherosclerotic coronary and carotid plaques. Our quantitative results indicate that plaque morphology and structure, vessel and plaque material properties, and pressure conditions all have considerable effects on flow and plaque stress/ strain behaviors. This FSI multi-component model provides more complete stress/strain analysis and better interpretation of information from magnetic resonance images and may lead to more accurate plaque vulnerability assessment and rupture predictions.

AB - Accuracy and reliability are extremely important when computational models are used to analyze biological systems and make diagnostic decisions and clinical predictions. In this paper, sensitivity analysis is performed for magnetic resonance imaging (MRI)-based three-dimensional (3D) models with multi-component plaque structure and fluid- structure interactions (FSI) to quantify effects of various controlling factors on stress/strain distributions in human atherosclerotic coronary and carotid plaques. Our quantitative results indicate that plaque morphology and structure, vessel and plaque material properties, and pressure conditions all have considerable effects on flow and plaque stress/ strain behaviors. This FSI multi-component model provides more complete stress/strain analysis and better interpretation of information from magnetic resonance images and may lead to more accurate plaque vulnerability assessment and rupture predictions.

KW - Artery

KW - Atherosclerotic plaque

KW - Carotid

KW - Coronary

KW - Fluid-structure interactions

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=80053457068&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:80053457068

SN - 0080444814

SN - 9780080444819

T3 - 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics

SP - 1009

EP - 1013

BT - 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics

T2 - 3rd M.I.T. Conference on Computational Fluid and Solid Mechanics

Y2 - 14 June 2005 through 17 June 2005

ER -

Sensitivity analysis of 3D MRI-based models with fluid-structure interactions for human atherosclerotic coronary and carotid plaques

Abstract

Publication series

Conference

Keywords

Other files and links

Fingerprint

Cite this