Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

Songming Peng; Jesse M. Zaretsky; Alphonsus H.C. Ng; William Chour; Michael T. Bethune; Jongchan Choi; Alice Hsu; Elizabeth Holman; Xiaozhe Ding; Katherine Guo; Jungwoo Kim; Alexander M. Xu; John E. Heath; Won Jun Noh; Jing Zhou; Yapeng Su; Yue Lu; Jami McLaughlin; Donghui Cheng; Owen N. Witte; David Baltimore; Antoni Ribas; James R. Heath

doi:10.1016/j.celrep.2019.07.106

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

Songming Peng
, Jesse M. Zaretsky
, Alphonsus H.C. Ng
, William Chour
, Michael T. Bethune
, Jongchan Choi
, Alice Hsu
, Elizabeth Holman
, Xiaozhe Ding
, Katherine Guo
, Jungwoo Kim
, Alexander M. Xu
, John E. Heath
, Won Jun Noh
, Jing Zhou
, Yapeng Su
, Yue Lu
, Jami McLaughlin
, Donghui Cheng
, Owen N. Witte

David Baltimore, Antoni Ribas, James R. Heath

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Peng et al. report a sensitive method to detect tumor-associated neoantigen-specific T cells. Neoantigens and fluorescent DNA barcodes, presented on nanoparticle scaffolds, permit multiplex capture and analysis of specific T cell populations from blood or tumor. Neoantigen-specific T cell numbers track tumor volume in a melanoma patient responding to immunotherapy.

Original language	English
Pages (from-to)	2728-2738.e7
Journal	Cell Reports
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.07.106
State	Published - Sep 3 2019

Keywords

cancer immunotherapy
microfluidics
nanotechnology
neoantigens
T cell receptor

Access to Document

10.1016/j.celrep.2019.07.106

Cite this

Peng, S., Zaretsky, J. M., Ng, A. H. C., Chour, W., Bethune, M. T., Choi, J., Hsu, A., Holman, E., Ding, X., Guo, K., Kim, J., Xu, A. M., Heath, J. E., Noh, W. J., Zhou, J., Su, Y., Lu, Y., McLaughlin, J., Cheng, D., ... Heath, J. R. (2019). Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Reports, 28(10), 2728-2738.e7. https://doi.org/10.1016/j.celrep.2019.07.106

@article{50e97b2ab1b74bc8910058ebe26a8a06,

title = "Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood",

abstract = "Peng et al. report a sensitive method to detect tumor-associated neoantigen-specific T cells. Neoantigens and fluorescent DNA barcodes, presented on nanoparticle scaffolds, permit multiplex capture and analysis of specific T cell populations from blood or tumor. Neoantigen-specific T cell numbers track tumor volume in a melanoma patient responding to immunotherapy.",

keywords = "cancer immunotherapy, microfluidics, nanotechnology, neoantigens, T cell receptor",

author = "Songming Peng and Zaretsky, \{Jesse M.\} and Ng, \{Alphonsus H.C.\} and William Chour and Bethune, \{Michael T.\} and Jongchan Choi and Alice Hsu and Elizabeth Holman and Xiaozhe Ding and Katherine Guo and Jungwoo Kim and Xu, \{Alexander M.\} and Heath, \{John E.\} and Noh, \{Won Jun\} and Jing Zhou and Yapeng Su and Yue Lu and Jami McLaughlin and Donghui Cheng and Witte, \{Owen N.\} and David Baltimore and Antoni Ribas and Heath, \{James R.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = sep,

day = "3",

doi = "10.1016/j.celrep.2019.07.106",

language = "English",

volume = "28",

pages = "2728--2738.e7",

journal = "Cell Reports",

issn = "2639-1856",

number = "10",

}

Peng, S, Zaretsky, JM, Ng, AHC, Chour, W, Bethune, MT, Choi, J, Hsu, A, Holman, E, Ding, X, Guo, K, Kim, J, Xu, AM, Heath, JE, Noh, WJ, Zhou, J, Su, Y, Lu, Y, McLaughlin, J, Cheng, D, Witte, ON, Baltimore, D, Ribas, A & Heath, JR 2019, 'Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood', Cell Reports, vol. 28, no. 10, pp. 2728-2738.e7. https://doi.org/10.1016/j.celrep.2019.07.106

TY - JOUR

T1 - Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

AU - Peng, Songming

AU - Zaretsky, Jesse M.

AU - Ng, Alphonsus H.C.

AU - Chour, William

AU - Bethune, Michael T.

AU - Choi, Jongchan

AU - Hsu, Alice

AU - Holman, Elizabeth

AU - Ding, Xiaozhe

AU - Guo, Katherine

AU - Kim, Jungwoo

AU - Xu, Alexander M.

AU - Heath, John E.

AU - Noh, Won Jun

AU - Zhou, Jing

AU - Su, Yapeng

AU - Lu, Yue

AU - McLaughlin, Jami

AU - Cheng, Donghui

AU - Witte, Owen N.

AU - Baltimore, David

AU - Ribas, Antoni

AU - Heath, James R.

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Peng et al. report a sensitive method to detect tumor-associated neoantigen-specific T cells. Neoantigens and fluorescent DNA barcodes, presented on nanoparticle scaffolds, permit multiplex capture and analysis of specific T cell populations from blood or tumor. Neoantigen-specific T cell numbers track tumor volume in a melanoma patient responding to immunotherapy.

AB - Peng et al. report a sensitive method to detect tumor-associated neoantigen-specific T cells. Neoantigens and fluorescent DNA barcodes, presented on nanoparticle scaffolds, permit multiplex capture and analysis of specific T cell populations from blood or tumor. Neoantigen-specific T cell numbers track tumor volume in a melanoma patient responding to immunotherapy.

KW - cancer immunotherapy

KW - microfluidics

KW - nanotechnology

KW - neoantigens

KW - T cell receptor

UR - https://www.scopus.com/pages/publications/85070931113

U2 - 10.1016/j.celrep.2019.07.106

DO - 10.1016/j.celrep.2019.07.106

M3 - Article

C2 - 31484081

AN - SCOPUS:85070931113

SN - 2639-1856

VL - 28

SP - 2728-2738.e7

JO - Cell Reports

JF - Cell Reports

IS - 10

ER -

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this