Sense and nonsense in genetic epidemiology: A critique of the statistical model of Williams and Iyer

A. C. Heath, N. G. Martin, L. J. Eaves

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The statistical model for the analysis of twin-family data of Williams and Iyer is examined. The model uses a large number of redundant parameters. It does not lead to quantitative predictions for new relationships. It allows for epistasis but not dominance. It makes assumptions about assortative mating which are inconsistent with any biologically plausible mechanism. It assumes that the environmental correlation between parent and offspring is due to the direct effect of the parental genotypes, not phenotypes, on offspring environment. Other models which avoid these problems are more appropriate for the analysis of extended twin-family data.

Original languageEnglish
Pages (from-to)557-563
Number of pages7
JournalActa geneticae medicae et gemellologiae
Volume33
Issue number4
DOIs
StatePublished - 1984
Externally publishedYes

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