TY - JOUR
T1 - Sense and immuno-sensibility
T2 - innate lymphoid cell niches and circuits
AU - McFarland, Adelle P.
AU - Colonna, Marco
N1 - Funding Information:
Marco Colonna receives research support from Pfizer.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2
Y1 - 2020/2
N2 - Tissue-resident lymphocytes that lack expression of rearranged antigen receptors and are lineage negative for classical T and B cell markers are collectively known as innate lymphoid cells (ILCs). The ILC family is remarkably heterogeneous and exhibits plasticity; however, mature ILCs can be grouped based on their steady state expression of distinct surface receptors and transcription factors as well as production of signature cytokines following activation. The study of ILC subsets in mouse and human tissues has revealed that the elicitation and magnitude of their effector functions are determined by a combination of extrinsic cues specific to the niches in which they reside. In this short review, we will summarize some recent findings related to tissue-specific signals that govern ILC responses and localization.
AB - Tissue-resident lymphocytes that lack expression of rearranged antigen receptors and are lineage negative for classical T and B cell markers are collectively known as innate lymphoid cells (ILCs). The ILC family is remarkably heterogeneous and exhibits plasticity; however, mature ILCs can be grouped based on their steady state expression of distinct surface receptors and transcription factors as well as production of signature cytokines following activation. The study of ILC subsets in mouse and human tissues has revealed that the elicitation and magnitude of their effector functions are determined by a combination of extrinsic cues specific to the niches in which they reside. In this short review, we will summarize some recent findings related to tissue-specific signals that govern ILC responses and localization.
UR - http://www.scopus.com/inward/record.url?scp=85076143623&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2019.11.003
DO - 10.1016/j.coi.2019.11.003
M3 - Review article
C2 - 31825814
AN - SCOPUS:85076143623
SN - 0952-7915
VL - 62
SP - 9
EP - 14
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -