TY - JOUR
T1 - Senior adult oncology
T2 - Clinical practice guidelines in oncology
AU - Hurria, Arti
AU - Browner, Ilene S.
AU - Cohen, Harvey Jay
AU - Denlinger, Crystal S.
AU - DeShazo, Mollie
AU - Extermann, Martine
AU - Ganti, Apar Kishor P.
AU - Holland, Jimmie C.
AU - Holmes, Holly M.
AU - Karlekar, Mohana B.
AU - Keating, Nancy L.
AU - McKoy, June
AU - Medeiros, Bruno C.
AU - Mrozek, Ewa
AU - O'Connor, Tracey
AU - Petersdorf, Stephen H.
AU - Rugo, Hope S.
AU - Silliman, Rebecca A.
AU - Tew, William P.
AU - Walter, Louise C.
AU - Weir, Alva B.
AU - Wildes, Tanya
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Cancer is the leading cause of death in women and men aged 60 to 79 years. The biologic characteristics of certain cancers are different in older patients compared with their younger counterparts, and older patients also have decreased tolerance to chemotherapy. Nevertheless, advanced age alone should not be the only criteria to preclude effective cancer treatment that could improve quality of life or lead to a survival benefit in older patients. Treatment should be individualized based the nature of the disease, the physiologic status of the patient, and patient preferences. Chronologic age is not reliable in estimating life expectancy, functional reserve, or the risk of treatment complications. Whether cancer treatment is appropriate may be best determined through careftil assessment of the older patient. CGA can be used to assess life expectancy and risk of morbidity from cancer in elderly patients, in turn enabling physicians to develop a coordinated plan for cancer treatment and guide interventions tailored to the patient's problems.
AB - Cancer is the leading cause of death in women and men aged 60 to 79 years. The biologic characteristics of certain cancers are different in older patients compared with their younger counterparts, and older patients also have decreased tolerance to chemotherapy. Nevertheless, advanced age alone should not be the only criteria to preclude effective cancer treatment that could improve quality of life or lead to a survival benefit in older patients. Treatment should be individualized based the nature of the disease, the physiologic status of the patient, and patient preferences. Chronologic age is not reliable in estimating life expectancy, functional reserve, or the risk of treatment complications. Whether cancer treatment is appropriate may be best determined through careftil assessment of the older patient. CGA can be used to assess life expectancy and risk of morbidity from cancer in elderly patients, in turn enabling physicians to develop a coordinated plan for cancer treatment and guide interventions tailored to the patient's problems.
KW - Advanced age
KW - Cancer treatment
KW - Comprehensive geriatric assessment
KW - NCCN clinical practice guidelines
KW - NCCN guidelines
KW - Older patient
KW - Senior adult elderly
UR - http://www.scopus.com/inward/record.url?scp=84856862112&partnerID=8YFLogxK
U2 - 10.6004/jnccn.2012.0019
DO - 10.6004/jnccn.2012.0019
M3 - Review article
C2 - 22308515
AN - SCOPUS:84856862112
SN - 1540-1405
VL - 10
SP - 162
EP - 209
JO - JNCCN Journal of the National Comprehensive Cancer Network
JF - JNCCN Journal of the National Comprehensive Cancer Network
IS - 2
ER -