Senescent glia spell trouble in Alzheimer’s disease

David Holtzman; Jason Ulrich

doi:10.1038/s41593-019-0395-2

Senescent glia spell trouble in Alzheimer’s disease

David Holtzman, Jason Ulrich

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

DNA damage or cellular stresses can induce senescence, and increased senescence with aging contributes to age-associated tissue damage, inflammation and disease. Zheng and colleagues report increased senescent oligodendrocyte progenitor cells around amyloid plaques. Therapeutically eliminating these senescent cells may influence the onset and progression of Alzheimer’s disease pathology.

Original language	English
Pages (from-to)	683-684
Number of pages	2
Journal	Nature neuroscience
Volume	22
Issue number	5
DOIs	https://doi.org/10.1038/s41593-019-0395-2
State	Published - May 1 2019

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Senescent glia spell trouble in Alzheimer’s disease

Abstract

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