Semipermeable hollow fiber phantoms for development and validation of perfusion-sensitive mr methods and signal models

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Abstract

Two semipermeable, hollow fiber phantoms for the validation of perfusion-sensitive magnetic resonance methods and signal models are described. Semipermeable hollow fibers harvested from a standard commercial hemodialysis cartridge serve to mimic tissue capillary function. Flow of aqueous media through the fiber lumen is achieved with a laboratory-grade peristaltic pump. Diffusion of water and solute species (e.g., Gd-based contrast agent) occurs across the fiber wall, allowing exchange between the lumen and the extralumenal space. Phantom design attributes include: i) small physical size, ii) easy and low-cost construction, iii) definable compartment volumes, and iv) experimental control over media content and flow rate.

Original languageEnglish
Pages (from-to)149-158
Number of pages10
JournalConcepts in Magnetic Resonance Part B: Magnetic Resonance Engineering
Volume39 B
Issue number3
DOIs
StatePublished - Aug 1 2011

Keywords

  • Dialyzer
  • Hollow fiber bioreactor
  • MR phantom design
  • Perfusion
  • Semi-permeable hollow fiber

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