Semi-automated quantification of the regional left ventricular response to dobutamine stress by Tissue Doppler echocardiography

William E. Katz, Sunil Mankad, William A. Mandarino, John Gorcsan

Research output: Contribution to journalArticle

Abstract

Tissue Doppler imaging (TDI) may quantify regional left ventricular (LV) function, but extraction of color-coded velocity data has previously required off-line visual comparison to a color velocity map. The objective was to assess the regional LV response to dobutamine stress using a new semi-automated TDI data analysis system. Eight patients, aged 60±12 yrs, with normal posterior wall function at rest and peak stress were studied. Color TDI M-modes (Toshiba 380A) were obtained at rest, at low dose (5 μg/kg/min) and at peak dobutamine stress (45±8 μg/kg/min). Endocardial velocity and time-velocity gradients (TVG) were plotted from a digital velocity matrix (examples shown). Baseline data were: peak systolic velocity 45 ± 22 mm/sec, systolic TVG 3.1 ± 0.9 sec-1, peak diastolic velocity 68 ± 41 mm/sec, and diastolic TVG 3.8 ± 1.5 sec-1. Peak systolic and diastolic velocities increased with low dose dobutamine to 66 ± 32*, and 74 ± 31* mm/sec, respectively (*p<0.05 vs. baseline). Further changes occurred at peak stress: peak systolic velocity increased to 106 ± 19 mm/sec*#, systolic TVG increased to 6.8 ± 2.7# sec-1, peak diastolic velocity increased to 89 ± 36 mm/sec*# and diastolic TVG increased to 6.4 ± 1.4 sec-1* (* p<0.001 vs. baseline, # p<0.05 vs. low dose). Conclusion: Semi-automated TDI analysis has potential to rapidly quantify regional LV function during dobutamine stress echocardiography.

Original languageEnglish
Number of pages1
JournalJournal of the American Society of Echocardiography
Volume10
Issue number4
StatePublished - Dec 1 1997
Externally publishedYes

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